Combat medic and biochemist Rebecca Chambers, the sole survivor of Bravo Team, joins a new S.T.A.R.S. strike force when rumour comes of another Umbrella experiment: hidden beneath the rocky cliffs of Caliban Cove, Maine, someone is building an army of the undead. Now the S.T.A.R.S. must battle more unspeakable horrors and stop a madman from unleashing the biohazard upon the world.