What might the significance of Deleuze and Guattari be in relation to the new and urgent set of concerns that the Anthropocene engenders? This special issue of Deleuze Studies will engage the many philosophical tools provided by Deleuze and Guattari and their interlocutors in order to critically approach our particularly tense moment in earth history. Simultaneously it asks how this moment could change the ways Deleuze and Guattari are further developed.